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Occult hematologic malignancy in routine tonsillectomy specimens: a single institutional experience and review of the literature.

常规扁桃体切除标本中的隐匿性血液系统恶性肿瘤:单一机构的经验和文献复习。

Abstract

Handling of tonsillectomy specimens often includes gross and histologic examination. The published incidence of occult malignancy in benign-appearing tonsils is vanishingly rare, and consequently some propose omitting histologic analysis in young patients without clinical risk factors for malignancy or grossly suspicious features.
At our institution, an occult Burkitt lymphoma in a grossly benign-appearing tonsil from an otherwise healthy 5-year-old prompted review of our cases. We retrospectively reviewed tonsillectomy findings over a 5-year period, excluding patients with known lymphoma or head and neck malignancies. A total of 740 patients were identified. All cases underwent gross and histologic examination.
Four additional malignancies were diagnosed, including a clinically unsuspected lymphoma in a 14-year-old patient. In our experience, although most tonsillar malignancies present with suspicious clinical or gross findings, occult malignancies do occur.
Recognition of these occult findings may facilitate early diagnosis and treatment; thus pathologic study of these specimens may still be justified.

摘要

研究扁桃体标本通常包括大体观察和组织学检查。貌似良性的扁桃体中隐匿性恶性肿瘤的发病率据报道几乎为零,因此有人提出,对于无恶性临床危险因素或非常可疑特点的年轻患者可忽略组织学分析。
在我们的机构,1个健康的5岁儿童临床表现温和的扁桃体发现隐匿性伯基特淋巴瘤促使我们对病例进行了复习。我们回顾性分析了5年内的扁桃体切除标本,不包括已知淋巴瘤或头颈部恶性肿瘤的患者。对所有740例患者进行了重新鉴定。所有病例均进行大体观察和组织学检查。
我们又确诊了4个恶性肿瘤,其中包括1名临床上没有怀疑淋巴瘤的14岁病人。根据我们的经验,虽然大多数扁桃体恶性肿瘤都有可疑的临床或大体表现,但隐匿性恶性肿瘤确实发生了。
认识到这些隐匿性表现可能有助于早期诊断和治疗。因此,对这些标本进行病理研究是十分合理的。

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