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Elevated factor IX activity is associated with an increased odds ratio for both arterial and venous thrombotic events.

IX因子活性的升高与动脉和静脉血栓形成事件的相对危险度增加相关。

Heikal NM,Murphy KK,Crist RA,Wilson AR,Rodgers GM,Smock KJ
阅读：798 American Journal of Clinical Pathology； 2013 November; 140 (5)

Abstract

Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for evaluation of a hypercoagulable state.
Patients were classified by arterial transient ischemic attack/stroke (TIA/stroke, n = 62) or venous thromboembolism (VTE, n = 19) events. FIX activity testing was performed on all 81 subjects and a reference group of 40 healthy individuals.
Thirteen (21%) of 62 subjects with TIA/stroke and 5 (26%) of 19 subjects with VTE had elevated FIX activity. Odds ratios for TIA/stroke and VTE in subjects with elevated FIX activity were 3.7 (95% confidence interval [CI], 0.76-17.65) and 6.8 (95% CI, 1.18-39.07), respectively.
Our findings suggest an association between elevated FIX levels and both arterial and venous thrombotic events.

摘要

IX因子（FIX）的升高被认为可能增加血栓的风险，但是这并没有得到很好证明。我们通过对81例65岁以下（平均47岁）进行高凝状态评估的成年受试者进行回顾性研究，试图确定FIX水平升高是否是血栓形成的危险因素。
患者分为动脉短暂性缺血性发作/卒中（TIA/卒中，N=62）或静脉血栓栓塞（VTE，N=19）事件。对所有81例受试者和40例健康个体对照组进行FIX活性测试。
在62例TIA/卒中受试者中有13例(21%)与FIX活性升高相关，在19例VTE受试者中有5例（26％）与FIX活性升高相关。FIX活性升高的受试者对于TIA/卒中和VTE的相对危险度分别为3.7（95％置信区间[CI]，0.76-17.65）和6.8（95％CI，1.18-39.07）。
我们的研究结果表明了FIX水平的升高与动脉和静脉血栓形成事件之间的相关性。

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