Clinicopathologic features of CD5-positive nodal marginal zone lymphoma.

CD5阳性的结内边缘区淋巴瘤的临床病理特点。

Jaso JM,Yin CC,Wang SA,Miranda RN,Jabcuga CE,Chen L,Medeiros LJ

阅读：906 American Journal of Clinical Pathology； 2013 November; 140 (5)

Abstract

To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL).
We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL.
Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months).
CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.

摘要

阐述7例CD5阳性的结内边缘区淋巴瘤（NMZL）患者的临床病理结果。
我们检索了10多年内的NMZL病例，并确定7例CD5阳性NMZL。对其临床表现、组织学特征以及免疫表型结果进行了回顾，并本组播散的频率与66例CD5阴性NMZL进行比较。

除了CD5表达，组织学和免疫表型结果是典型的NMZL。7例中有6例（86％）有膈上和膈下的淋巴结肿大，并且所有6例患者有骨髓受累。在CD5阴性组，28（42％）患者有膈上和膈下的淋巴结肿大，36（55％）有骨髓侵犯（P值分别为0.045和0.037）。7例中6例在最后一次随访时患者仍生存，中位随访时间为32个月（3-154个月）。

在NMZL中CD5表达与较高的播散频率相关，但患者有惰性的临床过程和良好的总生存率。