MACC1 is related to colorectal cancer initiation and early-stage invasive growth.

MACC1与大肠癌的发生和早期浸润性生长有关。

Ren B,Zakharov V,Yang Q,McMahon L,Yu J,Cao W

阅读：658 American Journal of Clinical Pathology； 2013 November; 140 (5)

Abstract

To investigate metastasis associated in colon cancer 1 (MACC1) and MET expression in colorectal adenoma, Tis, early-stage invasive (T1 and T2), and advanced adenocarcinoma with liver metastasis using immunohistochemistry.
Ninety-three paraffin-embedded colorectal tumor specimens were immunohistochemically analyzed for MACC1 and MET protein expression.
MACC1 expression was upregulated in the transition from adenoma to Tis; its expression was further elevated during tumor progression from Tis to early invasive carcinoma. MET expression was constant from adenoma to Tis and to T1 but significantly increased as tumor progression to T2. Both MACC1 and MET expression were enhanced in advanced carcinoma with liver metastasis.
Stepwise elevation of MACC1 expression in key points of colorectal cancer development suggests that MACC1 may contribute to cancer initiation and early invasive growth. High expression of both MACC1 and MET may relate to distant metastasis.

摘要

用免疫组织化学研究在大肠腺瘤、原位癌、早期浸润性癌（T1和T2）以及肝转移的进展期腺癌中结肠癌1基因（MACC1）和MET的表达与转移的相关性。
用免疫组化对93例石蜡包埋的大肠肿瘤标本的MACC1和MET蛋白表达情况进行分析。
从腺瘤到原位癌的过程中，MACC1表达上调；从原位癌到早期浸润癌中其表达进一步升高。从腺瘤、原位癌到T1期肿瘤，MET表达稳定；但随着肿瘤进展到T2，MET表达显着升高。在肝转移的进展期癌中，MACC1和MET表达都增强。
在大肠癌发展关键点，MACC1表达的逐步抬高表明MACC1可能会促进癌症的发生和早期浸润性生长。MACC1和MET同时高表达可能与远处转移相关。