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Solid Papillary Breast Carcinomas Resembling the Tall Cell Variant of Papillary Thyroid Neoplasms: A Unique Invasive Tumor With Indolent Behavior.

与高细胞亚型的甲状腺乳头状肿瘤相似的实性乳头状乳腺癌:一种具有惰性生物学行为的特殊浸润性肿瘤

Foschini MP,Asioli S,Foreid S,Cserni G,Ellis IO,Eusebi V,Rosai J

Abstract

Thirteen cases of invasive solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTC) are reported here. Some cases had long-term follow-up. BPTC is a special type of primary breast neoplasm showing a triple-negative profile but low aggressive potential. Knowledge on BPTC is still scanty; therefore, the aim of the present paper was to report on the features of an additional 13 cases. All the patients were female individuals, and the mean age at presentation was 62.6 years; nodule sizes ranged from 0.6 to 2.5 cm (average, 1.6 cm). All the cases were characterized on histology by papillary, follicular as well as solid structures. The cells were columnar, eosinophilic mostly with granular cytoplasms, rich in mitochondria, with the features of oncocytes in no fewer than 7 cases. Estrogen and progesterone receptors as well as HER2 were consistently negative. The Ki67 proliferative index was low. Markers consistent with thyroid origin, such as TTF1 and thyroglobulin, were negative. Five cases stained for mammoglobin and GATA 3 were positive. All cases proved to be invasive and 2 cases each experienced metastases to 1 lymph node (axillary and intramammary). One case of the latter had a local recurrence. Nevertheless, all the patients are alive, free of disease 24 to 132 months after surgery, of which 8 are without further treatment The present series confirms that BPTC is a primary breast tumor of low malignant potential.

摘要

这篇文章报道了13例与高细胞亚型的甲状腺乳头状肿瘤相似的浸润性实性乳头状乳腺癌(BPTC)。其中一些病例经过长期随访。BPTC是乳腺原发肿瘤的一种特殊类型,它具有“三阴”性乳腺癌特征但又仅有低度侵袭性。目前人们对于BPTC的了解仍然是有限的,因此,这篇文章旨在总结报道13例BPTC病例的特征。所有患者均为女性,平均年龄为62.6岁,结节大小0.6cm到2.5cm不等(平均1.6cm)。所有病例组织形态学均以乳头状、滤泡状和实性片状结构为特征。细胞为柱状,胞质主要为嗜酸性颗粒状,线粒体丰富,且至少有7例病例具有嗜酸细胞特征。雌激素和孕激素受体以及HER2均为阴性表达。Ki67增值指数比较低,甲状腺来源的标记物如TTF-1和甲状腺球蛋白也均为阴性。5例病例的乳腺珠蛋白和GATA 3为阳性表达。所有病例均被证实有浸润性生长,并且其中2例均有1枚淋巴结转移(腋窝和乳腺内)。其中1例曾局部复发过。然而,所有患者迄今为止均存活,她们均在手术后无病生存了24到132个月,有8位患者未进行过进一步治疗。这一系列数据显示BPTC是一种原发于乳腺的低度恶性潜能肿瘤。





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