Acute Myeloid Leukemia Genetics: Risk Stratification and Implications for Therapy.

急性髓性白血病的遗传学研究：危险分层及对治疗的影响。

Wang ML,Bailey NG

阅读：606 Archives of Pathology & Laboratory Medicine； Volume 139, Issue 10 (October 2015):1215-23

Abstract

Acute myeloid leukemia is a category of diseases with a common aggressive clinical presentation but with a prognosis and management that is dependent upon the underlying genetic characteristics of the neoplasm. The purpose of this brief review is to update the practicing pathologist on the current standard of care in the genetic evaluation of acute myeloid leukemia and to highlight future directions in the classification, genetic assessment, and management of these devastating diseases.

摘要

急性髓性白血病是一类临床常见的具有侵袭性特征的疾病，其预后和治疗却依赖于肿瘤的潜在遗传特征。本综述的目的是更新目前一线病理学者对急性髓性白血病遗传评价的现行标准，以便突出未来对此毁灭性疾病分类、遗传评估、治疗的发展方向。

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