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Breast cancer subtypes predispose the site of distant metastases.

乳腺癌亚型影响其远处转移部位

Soni A,Ren Z,Hameed O,Chanda D,Morgan CJ,Siegal GP,Wei S

Abstract

The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.
We explored the relationship between the clinicopathologic factors and the common sites of distant metastasis in 531 consecutive patients with advanced breast cancer.
Breast cancer subtype as a variable was significantly associated with all five common sites of relapse by multivariate analysis. The luminal tumors were remarkable for their significant bone-seeking phenotype and were less frequently observed in lung, brain, and pleural metastases and less likely to be associated with multiorgan relapse. The HER2 subtype demonstrated a significant liver-homing characteristic. African Americans were significantly less likely to have brain-only metastasis in patients with brain relapse.
These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.

摘要

好发乳腺癌转移的远处器官是什么位置,具有重要的临床意义。

我们连续对531例晚期乳腺癌患者临床病理因素和远处转移常见部位间的关系进行了探讨。

经多变量分析,乳腺癌亚型这一变量与5个常见复发部位均显着相关。管腔型肿瘤显着表现为亲骨表型,并较少见肺、脑、胸膜转移,不太可能与多脏器复发有关。HER2亚型表现出明显的肝脏归巢特征。具有脑部复发的非洲裔美国患者中,仅见脑部转移者明显较少。

这些发现进一步表明乳腺癌亚型不仅肿瘤特征不同,而且在肿瘤转移行为上也有差别,从而增加了运用这些知识为新诊断乳腺癌患者制定适当随访策略的可能性。

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