Context .- Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis. Objectives .- To characterize the anatomic distribution of SSA/P with and without cytologic dysplasia and to assess the demographics of these patients in a nationwide database. Design .- We retrospectively analyzed the database of Miraca Life Sciences Research Institute for a 1-year period. Patients with a diagnosis of SSA/P, SSA/P with low-grade cytologic dysplasia (SSA/P-LGD), SSA/P with high-grade cytologic dysplasia (SSA/P-HGD), or SSA/P with adenocarcinoma (SSA/P-ACA) were retrieved, and patients' age, sex, and specific anatomic location were analyzed. Results .- A total of 11 201 patients were identified, of which 10 646 (95.0%) had SSA/P, 514 (4.6%) had SSA/P-LGD, 39 (0.35%) had SSA/P-HGD, and 2 (0.018%) had SSA/P-ACA. All SSA/Ps and more advanced lesions were significantly more common in the proximal colon-SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%), and SSA/P-ACA (100%)-than in either the transverse (18.8%, 17.8%, 10.0%, and 0%, respectively) or the distal (19.9%, 21.0%, 10.0%, and 0%, respectively) colon, P < .001. Sessile serrated adenoma/polyp with cytologic dysplasia was most commonly found in the ascending colon (LGD, 31.6%) and cecum (HGD, 37.5%). Advanced SSA/Ps were disproportionally more common among older women. Conclusions .- Sessile serrated adenomas/polyps with and without cytologic dysplasia and carcinoma are predominantly found in the cecum and ascending colon, whereas there is low prevalence in both the transverse and distal colon. Confirmation of previously published data regarding demographics of advanced lesions among a different cohort and including newer (broader) criteria suggests these criteria are valid.
结果：总计11201例，其中10646例（95.0%）有SSA/P，514例（4.6%）有SSA/P-LGD，39例（0.35%）有SSA/P-HGD，2例（0.018%）有SSA/P-ACA，所有SSA/Ps和更具进展的病变明显多见于近端结肠-SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%)和SSA/P-ACA (100%)，高于横结肠(分别为18.8%, 17.8%, 10.0%和 0%)或远端结肠 (19.9%, 21.0%, 10.0%和0%)。无蒂锯齿状腺瘤/息肉伴细胞学异型增生最常见升结肠（LGD,31.6%)和盲肠（HGD,37.5%）。进展性SSA/Ps偏向于老年女性较常见。