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The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.

Thompson ED,Roberts NJ,Wood LD,Eshleman JR,Goggins MG,Kern SE,Klein AP,Hruban RH
阅读：208 Modern Pathology； Volume 33 Issue 12, December 2020:2544-2563 

Abstract

The publication of the "Pan-Cancer Atlas" by the Pan-Cancer Analysis of Whole Genomes Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC), provides a wonderful opportunity to reflect on where we stand in our understanding of the genetics of pancreatic cancer, as well as on the opportunities to translate this understanding to patient care. From germline variants that predispose to the development of pancreatic cancer, to somatic mutations that are therapeutically targetable, genetics is now providing hope, where there once was no hope, for those diagnosed with pancreatic cancer.

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