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Low-grade fibromatosis-like spindle cell carcinoma of the breast.

乳腺低级别纤维瘤病样梭形细胞癌

Abstract

Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Recognition of a proliferation of cytologically bland spindle cells with areas of epithelial differentiation in combination with immunohistochemistry using antibodies against cytokeratins and myoepithelial markers should aid in producing a definitive diagnosis. These tumors can be locally aggressive with an increased incidence of local recurrence, but the potential for lymph node or distant metastasis is low. Complete excision with adequate margins is considered curative in the majority of cases.

摘要

乳腺低级别纤维瘤病样梭形细胞癌是一种罕见肿瘤,代表高度异质性乳腺化生性癌的一种变型。因为这类肿瘤与纯的纤维瘤病相似,具有局部复发倾向,并在乳腺化生性癌中预后良好,所以这类肿瘤应区分出来。这类肿瘤的诊断具有潜在挑战性,特别是粗针活检标本,因为其形态学与其他低级别梭形细胞病变重叠。识别细胞学温和的梭形细胞伴上皮分化区域,结合细胞角蛋白和肌上皮细胞标记物免疫组织化学染色有助于明确诊断。这类肿瘤可呈局部侵袭伴局部多次复发,但淋巴结或远处转移潜能低。大多数病例经完整切除并保留充分切缘可治愈。
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