Diagnosis of splenic B-cell lymphomas in the bone marrow: a review of histopathologic, immunophenotypic, and genetic findings.

骨髓中脾脏B细胞淋巴瘤的诊断：组织病理学、免疫表型及遗传学综述

Behdad A,Bailey NG

阅读：418 Archives of Pathology & Laboratory Medicine； Volume 138, Issue 10 (October 2014):1295-301

Abstract

Splenic B-cell lymphomas are a heterogeneous group of diseases comprising several entities that exhibit overlapping features. Diagnosis of these lymphomas has been reliant on the histopathologic examination of the spleen. However, with advances in diagnostic modalities and therapy, splenectomy is not commonly performed, and diagnosis and subclassification must be rendered based on the blood and bone marrow findings. In this brief review, we summarize the morphologic, immunophenotypic, and genetic findings of splenic B-cell lymphomas in the blood and bone marrow.

摘要

脾脏B细胞淋巴瘤是一组异质性疾病，包括特征存在重叠的几个亚型。这些淋巴瘤的诊断依赖于脾脏组织病理学检查。然而，随着诊断和治疗方法的进步，脾脏切除已经不常见了，所以诊断及分类需要依赖于血和骨髓的发现。在这篇简短的综述中，我们总结了血及骨髓标本中，脾脏B细胞淋巴瘤的形态学、免疫表型及遗传学表现。

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