This article is a brief review of the clinical, radiographic, and pathologic features of Pick disease. It is directed toward residents and fellows in training as well as practicing physicians who might wish to find a concise treatise on this clinicopathologic entity. The pathogenesis and genetics of this disorder are discussed. Included are medical journal articles accessed from computerized medical literature searches of articles published in the last 10 years. Pertinent images have been included where necessary. Although ubiquitously discussed in medical school and residency, Pick disease is nevertheless a relatively uncommon clinicopathologic entity. Recognition of its clinical and pathologic manifestations is critical in correctly diagnosing this illness and subsequently educating family members of the deceased.