Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.

Skalova A,Vanecek T,Martinek P,Weinreb I,Stevens TM,Simpson RHW,Hyrcza M,Rupp NJ,Baneckova M,Michal M,Slouka D,Svoboda T,Metelkova A,Etebarian A,Pavelka J,Potts SJ,Christiansen J,Steiner P,Michal M

阅读：908 American Journal of Surgical Pathology； Volume 42, February 2018, Issue 2, pp. e11-e27,141-278:234-246

Abstract

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation.

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.

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