Simultaneous Occurrence of Focal Nodular Hyperplasia and HNF1A-inactivated Hepatocellular Adenoma: A Collision Tumor Simulating a Composite FNH-HCA.

局灶性结节性增生和HNF1A失活型肝细胞腺瘤同时发生：类似于复合性FNH-HCA的碰撞瘤

Shih A,Lauwers GY,Balabaud C,Bioulac-Sage P,Misdraji J

阅读：490 American Journal of Surgical Pathology； Volume 39,September 2015,Issue 9 pp: 1159-1304:1296-300

Abstract

Mixed focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) within a single tumor mass is rarely reported, and most of these cases are examples of tumors with features intermediate between FNH and HCA. Although a few reported cases are probably examples of true mixed tumors, none was evaluated immunohistochemically or confirmed by molecular analysis. We report a mixed FNH and HCA arising in a woman with several HNF1A-inactivated adenomas. Our case is the first case of mixed FNH and HNF1A-inactivated HCA documented by immunohistochemistry.

摘要

同一个肿瘤内局灶性结节性增生（FNH）和肝细胞腺瘤（HCA）混合性存在，罕有报道，其中大多数病例具有介于FNH和HCA之间的组织学特征。尽管少数病例报道可能是真正的混合性肿瘤，但均无免疫组化或分子学分析证实。本文报道了一例混合性FNH-HCA，女性病人，有数个HNF1A失活型肝细胞腺瘤。我们的病例是通过免疫组化证实的第一例混合性FNH-HNF1A失活型HCA。

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