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Prognostic role of osteopontin expression in malignant pleural mesothelioma.

Cappia S,Righi L,Mirabelli D,Ceppi P,Bacillo E,Ardissone F,Molinaro L,Scagliotti GV,Papotti M
阅读：299 American Journal of Clinical Pathology； 2008 July; 130 (1)

Abstract

Malignant pleural mesothelioma (MPM) represents highly aggressive neoplasms with a mean survival of approximately 10 months. Osteopontin, a glycoprotein involved in cell-matrix interactions correlated with invasion and metastatic spread in several tumors, has recently been proposed as a serum marker of MPM in asbestos-exposed subjects. The aim of this study was to define the prognostic role of osteopontin in MPM. For the study, 32 long-term survivors (>24 months) and a random sample of 69 short-term survivors (

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